Childhood discoid lupus in identical twins.

We report the exceptional case of 11-year-old identical male twins who both developed discoid lupus erythematosus lesions. Although systemic lupus erythematosus has often been reported in identical twins, discoid lupus erythematosus has only occasionally been described, with only one other case in twin children, as far as we are aware.

Temporary localized hypertrichosis after henna pseudotattoo.

We report the case of a 5-year-old boy who had a temporary dragon-shaped henna pseudotattoo, reinforced 4 days later. Two weeks later, as the pseudotattoo began to disappear, hypertrichosis developed in the area corresponding to the previous psuedotattoo. Skin biopsy showed an increase in vellus hair follicles, with slight peripheral fibrosis. After 4 months, the hypertrichosis resolved spontaneously.

Lentigo maligno tratado con crema de imiquimod al 5 % / Lentigo maligna treated with 5% imiquimod cream

El lentigo maligno (LM) se considera el estadio in situ del lentigo maligno melanoma. Se presenta clínicamente como una mácula pigmentada de forma y tonalidad irregulares. Del 30 al 35 % de los lentigos malignos no tratados pueden progresar a un lentigo maligno melanoma. El tratamiento de elección de esta patología es la escisión quirúrgica con márgenes de 0,5 cm de piel clínicamente normal alrededor de la lesión o la microcirugía de Mohs. El imiquimod es un inmunomodulador tópico que estimula tanto la inmunidad adquirida como la innata. Presentamos el caso de una paciente con LM tratado con el imiquimod en crema al 5 % con excelente respuesta terapéutica

Lentigo maligna (LM) is considered to be an in-situ stage of lentigo maligna melanoma. Clinically, it presents as a pigmented macule, irregular in shape and tone. 30 % to 35 % of untreated lentigo malignas can progress into lentigo maligna melanoma. The treatment of choice for this pathology is surgical excision with margins of 0.5 cm. of clinically normal skin around the lesion, or Mohs microsurgery. Imiquimod is a topical immunomodulator that stimulates both acquired and innate immunity. We present the case of a patient with LM, treated with 5 % imiquimod cream, with an excellent therapeutic response

Epidermodisplasia verruciforme / Epidermodysplasia verruciformis

Mujer latinoamericana de 50 años que acudió a la consulta por lesiones pruriginosas de reciente aparición en los brazos y muslos. En la exploración observamos múltiples pápulas planas en las extremidades, así como máculas hipopigmentadas en el tronco que, según refería la paciente, comenzaron a aparecer en la infancia. Se realizó el estudio histológico de ambos tipos de lesiones en el que se apreciaron en las capas altas de la epidermis unos queratinocitos aumentados de tamaño con citoplasma de color azul pálido. Se han descrito más de 20 tipos de virus del papiloma humano (VPH) asociados a epidermodisplasia verruciforme (EV) (VPH-EV). Aunque antes se pensaba que estos eran específicos de la EV, gracias a nuevas técnicas de biología molecular, se han aislado secuencias de VPH-EV en enfermedades cutáneas con hiperproliferación epidérmica tanto benignas como malignas en población inmunocompetente

We present the case of a 50-year-old Latin American woman who consulted her physician because of recent pruritic lesions on her arms and thighs. During the examination, we observed multiple flat papules on the limbs, as well as hypopigmented macules on the trunk which, according to the patient, began to appear during childhood. A histological study was performed on both types of lesions, and showed some enlarged keratinocytes with light blue cytoplasm in the upper layers of the epidermis. More than 20 types of HPV associated with EV (HPV-EV) have been described. Although it was previously thought that these were specific to EV, new molecular biology techniques have made it possible to isolate HPV-EV sequences in skin diseases, both benign and malignant, with epidermal hyperproliferation in the immunocompetent population

[Epidermodysplasia verruciformis]. / Epidermodisplasia verruciforme.

We present the case of a 50-year-old Latin American woman who consulted her physician because of recent pruritic lesions on her arms and thighs. During the examination, we observed multiple flat papules on the limbs, as well as hypopigmented macules on the trunk which, according to the patient, began to appear during childhood. A histological study was performed on both types of lesions, and showed some enlarged keratinocytes with light blue cytoplasm in the upper layers of the epidermis. More than 20 types of HPV associated with EV (HPV-EV) have been described. Although it was previously thought that these were specific to EV, new molecular biology techniques have made it possible to isolate HPV-EV sequences in skin diseases, both benign and malignant, with epidermal hyperproliferation in the immunocompetent population.

[Lentigo maligna treated with 5% imiquimod cream]. / Lentigo maligno tratado con crema de imiquimod al 5%

Lentigo maligna (LM) is considered to be an in-situ stage of lentigo maligna melanoma. Clinically, it presents as a pigmented macule, irregular in shape and tone. 30% to 35% of untreated lentigo malignas can progress into lentigo maligna melanoma. The treatment of choice for this pathology is surgical excision with margins of 0.5 cm. of clinically normal skin around the lesion, or Mohs microsurgery. Imiquimod is a topical immunomodulator that stimulates both acquired and innate immunity. We present the case of a patient with LM, treated with 5% imiquimod cream, with an excellent therapeutic response.